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Data de publicació

2025-05-09

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cc-by (c) Casadevall et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222035

Metabolomic Plasma Profile of Chronic Obstructive Pulmonary Disease Patients

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Recurs relacionat

https://doi.org/10.3390/ijms26104526

Resum

The analysis of blood metabolites may help identify individuals at risk of having COPD and offer insights into its underlying pathophysiology. This study aimed to identify COPD-related metabolic alterations and generate a biological signature potentially useful for screening purposes. Plasma metabolomic profiles from 91 COPD patients and 91 controls were obtained using complementary semi-targeted and untargeted LC-MS approaches. Univariate analysis identified metabolites with significant differences between groups, and enrichment analysis highlighted the most affected metabolic pathways. Multivariate analysis, including ROC curve assessment and machine learning algorithms, was applied to assess the discriminatory capacity of selected metabolites. After adjustment for major potential confounders, 56 metabolites showed significant differences between COPD patients and controls. The enrichment analysis revealed that COPD-associated metabolic alterations primarily involved lipid metabolism (especially fatty acids and acylcarnitines), followed by amino acid pathways and xenobiotics. A panel of 10 metabolites, mostly related to lipid metabolism, demonstrated high discriminatory performance for COPD (ROC-AUC: 0.916; 90.1% sensitivity and 89% specificity). These findings may contribute to improving screening strategies and a better understanding of COPD-related metabolic changes. However, our findings remain exploratory and should be interpreted with caution, needing further validation and mechanistic studies.

Matèries

Malalties pulmonars obstructives cròniques, Bioquímica clínica

Matèries (anglès)

Chronic obstructive pulmonary diseases, Clinical biochemistry

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

Citació

CASADEVALL, Carme, et al. Metabolomic Plasma Profile of Chronic Obstructive Pulmonary Disease Patients. International Journal of Molecular Sciences. 2025. Vol. 26, num. 10. ISSN 1422-0067. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/222035

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