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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/201920
Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate
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We show that catalyst-free aqueous solutions of hyperpolarized [1-13C]succinate can be produced using parahydrogen-induced polarization (PHIP) and a combination of homogeneous and heterogeneous catalytic hydrogenation reactions. We generate hyperpolarized [1-13C]fumarate via PHIP using para-enriched hydrogen gas with a homogeneous ruthenium catalyst, and subsequently remove the toxic catalyst and reaction side products via a purification procedure. Following this, we perform a second hydrogenation reaction using normal hydrogen gas to convert the fumarate into succinate using a solid Pd/Al2O3 catalyst. This inexpensive polarization protocol has a turnover time of a few minutes, and represents a major advance for in vivo applications of [1-13C]succinate as a hyperpolarized contrast agent.
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EILLS, James, PICAZO FRUTOS, Román, BURUEVA, Dudari b., KOVTUNOVA, Larisa m., AZAGRA, Marc, MARCO RIUS, Irene, BUDKER, Dmitry, KOPTYUG, Igor v.. Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate. _Chemical Communications_. 2023. Vol. 59, núm. 62, pàgs. 9509-9512. [consulta: 25 de febrer de 2026]. ISSN: 2050-5620. [Disponible a: https://hdl.handle.net/2445/201920]