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2023_CheCom_Combined_EillsJ.pdf (850.8 KB)

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2023-07-14

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cc by-nc (c) Eills, James et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/201920

Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate

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https://doi.org/10.1039/d3cc01803b

Abstract

We show that catalyst-free aqueous solutions of hyperpolarized [1-13C]succinate can be produced using parahydrogen-induced polarization (PHIP) and a combination of homogeneous and heterogeneous catalytic hydrogenation reactions. We generate hyperpolarized [1-13C]fumarate via PHIP using para-enriched hydrogen gas with a homogeneous ruthenium catalyst, and subsequently remove the toxic catalyst and reaction side products via a purification procedure. Following this, we perform a second hydrogenation reaction using normal hydrogen gas to convert the fumarate into succinate using a solid Pd/Al2O3 catalyst. This inexpensive polarization protocol has a turnover time of a few minutes, and represents a major advance for in vivo applications of [1-13C]succinate as a hyperpolarized contrast agent.

Subject

Hidrogenació, Processos químics

Subject (English)

Hydrogenation, Chemical processes

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citation

EILLS, James, et al. Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate. Chemical Communications. 2023. Vol. 59, num. 62, pags. 9509-9512. ISSN 2050-5620. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/201920

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