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2019-02-19

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cc-by-nc (c) Moliner, Pedro et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/171984

Association between norepinephrine levels and abnormal iron status in patients with chronic heart failure: is iron deficiency more than a comorbidity?

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https://doi.org/10.1161/JAHA.118.010887

Abstract

Background-¿Mechanisms underlying iron homeostasis dysregulation in patients with chronic heart failure remain unsettled. In cardiomyocyte models, norepinephrine may lead to intracellular iron depletion, but the potential association between catecholamines (sympathetic activation markers) and iron metabolism biomarkers in chronic heart failure is unknown. Methods and Results-¿In this cross-sectional analysis, we studied the association between plasma norepinephrine levels and serum iron status biomarkers indicating iron storage (ferritin), iron transport (transferrin saturation), and iron demand (soluble transferrin receptor) in a prospective cohort of 742 chronic heart failure patients (mean age, 72 11 years; 56% male). Impaired iron status was defined as ferritin 0.05). Adjusted norepinephrine marginal means were significantly higher in patients with impaired iron status compared with those with normal iron status (528 pg/mL [505-551] versus 482 pg/mL [448-518], respectively; P=0.038). Conclusions-¿In chronic heart failure patients, increased sympathetic activation estimated with norepinephrine levels is associated with impaired iron status and, particularly, dysregulation of biomarkers suggesting impaired iron transport and increased iron demand. Whether the relationship between norepinephrine and iron metabolism is bidirectional and entails causality need to be elucidated in future research. (J Am Heart Assoc. 2019;8:e010887. DOI: 10.1161/JAHA.118.010887.)

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Anèmia, Insuficiència cardíaca, Sistema nerviós simpàtic

Subject (English)

Anemia, Heart failure, Sympathetic nervous system

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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MOLINER, Pedro, et al. Association between norepinephrine levels and abnormal iron status in patients with chronic heart failure: is iron deficiency more than a comorbidity?. Journal of the American Heart Association. 2019. Vol. 8, num. 4. ISSN 2047-9980. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/171984

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