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Article

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Accepted version

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2020-08-08

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/178996

Lack of astrocytic glycogen alters synaptic plasticity but not seizure susceptibility

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https://doi.org/10.1007/s12035-020-02055-5

Abstract

Brain glycogen is mainly stored in astrocytes. However, recent studies both in vitro and in vivo indicate that glycogen also plays important roles in neurons. By conditional deletion of glycogen synthase (GYS1), we previously developed a mouse model entirely devoid of glycogen in the central nervous system (GYS1Nestin-KO). These mice displayed altered electrophysiological properties in the hippocampus and increased susceptibility to kainate-induced seizures. To understand which of these functions are related to astrocytic glycogen, in the present study, we generated a mouse model in which glycogen synthesis is eliminated specifically in astrocytes (GYS1Gfap-KO). Electrophysiological recordings of awake behaving mice revealed alterations in input/output curves and impaired long-term potentiation, similar, but to a lesser extent, to those obtained with GYS1Nestin-KO mice. Surprisingly, GYS1Gfap-KO mice displayed no change in susceptibility to kainate-induced seizures as determined by fEPSP recordings and video monitoring. These results confirm the importance of astrocytic glycogen in synaptic plasticity.

Subject

Glicogen, Epilèpsia, Astròcits, Metabolisme

Subject (English)

Glycogen, Epilepsy, Astrocytes, Metabolism

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Publicacions de projectes de recerca finançats per la UE

Citation

DURAN, Jordi, et al. Lack of astrocytic glycogen alters synaptic plasticity but not seizure susceptibility. Molecular Neurobiology. 2020. Vol. 57, num. 11, pags. 4657-4666. ISSN 0893-7648. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/178996

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