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From bench to bedside Calprotectin (S100A8 S100A9) as a biomarker_FrontiersInImmunology.pdf (2.57 MB)

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2022-11-03

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cc by (c) Inciarte Mundo, José et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/209129

From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis

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https://doi.org/10.3389/fimmu.2022.1001025

Abstract

S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration and modulation of neutrophils and macrophages. Higher calprotectin levels have been found in synovial fluid, plasma, and serum from RA patients. Recent studies have demonstrated better correlations between serum or plasma calprotectin and composite inflammatory disease activity indexes than c-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR). Calprotectin serum levels decreased after treatment, independently of the DMARD type or strategy. Calprotectin has shown the strongest correlations with other sensitive techniques to detect inflammation, such as ultrasound. Calprotectin independently predicts radiographic progression. However, its value as a biomarker of treatment response and flare after tapering is unclear. This update reviews the current understanding of calprotectin in RA and discusses possible applications as a biomarker in clinical practice.

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Artritis reumatoide, Marcadors bioquímics

Subject (English)

Rheumatoid arthritis, Biochemical markers

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

INCIARTE MUNDO, José, FRADE SOSA, Beatriz and SANMARTÍ SALA, Raimon. From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis. Frontiers In Immunology. 2022. Vol. 13, num. 1001025. ISSN 1664-3224. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/209129

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