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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/122757
IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy
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BACKGROUND: Difficulties to disentangle the protective versus
exposure role of anti-malarial antibodies hamper the
identification of clinically-relevant immune targets. Here,
factors affecting maternal IgG and IgMs against Plasmodium
falciparum antigens, as well as their relationship with parasite
infection and clinical outcomes, were assessed in mothers and
their children. Antibody responses among 207 Mozambican pregnant
women at delivery against MSP119, EBA175, AMA1, DBLalpha and
parasite lysate (3D7, R29 and E8B parasite lines), as well as
the surface of infected erythrocytes, were assessed by
enzyme-linked immunosorbent assay and flow cytometry. The
relationship between antibody levels, maternal infection and
clinical outcomes was assessed by multivariate regression
analysis. RESULTS: Placental infection was associated with an
increase in maternal levels of IgGs and IgMs against a broad
range of parasite antigens. The multivariate analysis including
IgGs and IgMs showed that the newborn weight increased with
increasing IgG levels against a parasite lysate, whereas the
opposite association was found with IgMs. IgGs are markers of
protection against poor pregnancy outcomes and IgMs of parasite
exposure. CONCLUSIONS: Adjusting the analysis for the
simultaneous effect of IgMs and IgGs can contribute to account
for heterogeneous exposure to P. falciparum when assessing
immune responses effective against malaria in pregnancy.
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MAYOR APARICIO, Alfredo gabriel, DOBAÑO, Carlota, NHABOMBA, Augusto j., GUINOVART, Caterina, JIMÉNEZ, Alfons, MANACA, Maria nélia, AGUILAR, Ruth, BARBOSA, Arnoldo, RODRIGUEZ, Mauricio h., CISTERÓ, Pau, QUIMICE, Lazaro m., MENÉNDEZ, Clara, APONTE, John j., ORDI I MAJÀ, Jaume, CHITNIS, Chetan e., ALONSO, Pedro. IgM and IgG against Plasmodium falciparum lysate as surrogates
of malaria exposure and protection during pregnancy. _Malaria Journal_. 2018. Vol. 17, núm. 182. [consulta: 7 de gener de 2026]. ISSN: 1475-2875. [Disponible a: https://hdl.handle.net/2445/122757]