Predicting ovarian-cancer burden in Catalonia by 2030: an age-period-cohort modelling

Abstract

Ovarian cancer is the most lethal gynaecological cancer in very-high-human-developmentindex regions. Ovarian cancer incidence and mortality rates are estimated to globally rise by 2035; although incidence and mortality rates depend on the region and prevalence of the associated risk factors. The aim of this study is to assess changes in incidence and mortality of ovarian cancer in Catalonia by 2030. Bayesian autoregressive age-period-cohort models were used to predict the burden of OC incidence and mortality rates for the 2015-2030 period. Incidence and mortality rates of ovarian cancer are expected to decline in Catalonia by 2030 in women ≥ 45 years of age. A decrease in ovarian-cancer risk was observed with increasing year of birth; with a rebound in women born in the 1980s. A decrease in mortality was observed for the period of diagnosis and period of death. Nevertheless; ovarian-cancer mortality remains higher among older women compared to other age groups. Our study summarizes the most plausible scenario for ovarian-cancer changes in terms of incidence and mortality in Catalonia by 2030; which may be of interest from a public health perspective for policy implementation.