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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183605
Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters
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Here, we present a new stereoselective alkylation of titanium(IV) enolates of chiral N-acyl oxazolidinones with tert-butyl peresters from Cα-branched aliphatic carboxylic acids, which proceeds through the decarboxylation of the peresters and the subsequent formation of alkyl radicals to produce the alkylated adducts with an excellent diastereoselectivity. Theoretical calculations account for the observed reactivity and the outstanding stereocontrol. Importantly, the resultant compounds can be easily converted into ligands for asymmetric and catalytic transformations.
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PÉREZ-PALAU, Marina, et al. Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters. Organic Letters. 2021. Vol. 23, num. 22, pags. 8852-8856. ISSN 1523-7060. [consulted: 17 of June of 2026]. Available at: https://hdl.handle.net/2445/183605