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s41467-021-26591-3.pdf (3.95 MB)

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2021-11-12

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cc by Roux, Anabel-Lise Le et al, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181271

Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

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https://doi.org/10.1038/s41467-021-26591-3

Resum

In many physiological situations, BAR proteins reshape membranes with pre-existing curvature (templates), contributing to essential cellular processes. However, the mechanism and the biological implications of this reshaping process remain unclear. Here we show, both experimentally and through modelling, that BAR proteins reshape low curvature membrane templates through a mechanochemical phase transition. This phenomenon depends on initial template shape and involves the co-existence and progressive transition between distinct local states in terms of molecular organization (protein arrangement and density) and membrane shape (template size and spherical versus cylindrical curvature). Further, we demonstrate in cells that this phenomenon enables a mechanotransduction mode, in which cellular stretch leads to the mechanical formation of membrane templates, which are then reshaped into tubules by BAR proteins. Our results demonstrate the interplay between membrane mechanics and BAR protein molecular organization, integrating curvature sensing and generation in a comprehensive framework with implications for cell mechanical responses.

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Reproducció del document publicat a: https://doi.org/10.1038/s41467-021-26591-3

Matèries

Química orgànica, Proteïnes

Matèries (anglès)

Chemistry, Organic, Proteins

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

ROUX, Anabel-lise le, TOZZI, Caterina, WALANI, Nikhil, QUIROGA, Xarxa, ZALVIDEA, Dobryna, TREPAT GUIXER, Xavier, STAYKOVA, Margarita, ARROYO, Marino, ROCA-CUSACHS SOULERE, Pere. Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization. _Nature Communications_. 2021. Vol.  vol 12. [consulta: 29 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/181271]

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