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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/158199
Combined buckwheat d-fagomine and fish omega-3 pufas stabilize the populations of gut prevotella and bacteroides while reducing weight gain in rats
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Some functional food components may help maintain homeostasis by promoting balanced gut microbiota. Here, we explore the possible complementary effects of d-fagomine and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA 1:1) on putatively beneficial gut bacterial strains. Male Sprague-Dawley rats were supplemented with d-fagomine, ω-3 PUFAs, or both, for 23 weeks. Bacterial subgroups were evaluated in fecal DNA by quantitative real-time polymerase chain reaction (qRT-PCR) and short-chain fatty acids were determined by gas chromatography. We found that the populations of the genus Prevotella remained stable over time in animals supplemented with d-fagomine, independently of ω-3 PUFA supplementation. Animals in these groups gained less weight than controls and rats given only ω-3 PUFAs. d-Fagomine supplementation together with ω-3 PUFAs maintained the relative populations of Bacteroides. ω-3 PUFAs alone or combined with d-fagomine reduced the amount of acetic acid and total short-chain fatty acids in feces. The plasma levels of pro-inflammatory arachidonic acid derived metabolites, triglycerides and cholesterol were lower in both groups supplemented with ω-3 PUFAs. The d-fagomine and ω-3 PUFAs combination provided the functional benefits of each supplement. Notably, it helped stabilize populations of Prevotella in the rat intestinal tract while reducing weight gain and providing the anti-inflammatory and cardiovascular benefits of ω-3 PUFAs
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HEREU, Mercè, RAMOS ROMERO, Sara, MARÍN-VALLS, Roser, AMÉZQUETA, Susana, MIRALLES PÉREZ, Bernat, ROMEU FERRAN, Marta, MÉNDEZ, Lucía, MEDINA, Isabel, TORRES SIMÓN, Josep lluís. Combined buckwheat d-fagomine and fish omega-3 pufas stabilize the populations of gut prevotella and bacteroides while reducing weight gain in rats. _Nutrients_. 2019. Vol. 11, núm. 11, pàgs. 2606. [consulta: 24 de gener de 2026]. ISSN: 2072-6643. [Disponible a: https://hdl.handle.net/2445/158199]