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The Role of Audiometry prior to High-Dose Cisplatin in Patients with Head and Neck Cancer.
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To analyze the role of audiometry in considering change to a less ototoxic treatment in head and neck cancer (HNC) patients.Consecutive patients prescribed high-dose cisplatin (100 mg/m2) between January 2013 and February 2015 were enrolled. Audiometry was performed at baseline and before cisplatin. Change to a less ototoxic agent or reduced cisplatin dose was considered with audiometric decreases >25 dB.A total of 103 patients were included; the median age of the patients was 59 years (range 18-75). Cisplatin was intended curative (58%), adjuvant (32%), or palliative (10%). Forty-two participants (41%) did not commence high-dose cisplatin because of baseline audiometric alterations. Of 61 patients treated with high-dose cisplatin, 40 (66%) showed marked ototoxicity at the end of treatment. The mean hearing loss between initial and final audiometries showed a hearing loss at 4 and 8 kHz in both ears (p = 0.002). Thirteen patients switched to carboplatin and 15 to a lower dose of cisplatin. The outcome was not significantly altered when cisplatin was replaced with carboplatin or cetuximab.Audiometric alterations are common in HNC with high-dose cisplatin, and switching to a less ototoxic regimen does not adversely affect outcome. Audiometric examination could help to prevent hearing loss in this population.© 2017 S. Karger AG, Basel.
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GRAU DE CASTRO, Juan jose, CABALLERO BORREGO, Miguel, MACKERS IGLESIAS, Paula, REIG TORRAS, Oscar, BUXO ORRA, Elvira, NAVARRETE DURAN, Pilar, BLANCH ANDREU, Jordi, GRAU JUNYENT, Josep m.. The Role of Audiometry prior to High-Dose Cisplatin in Patients with Head and Neck Cancer.. _Oncology_. 2017. Vol. 93, núm. 2, pàgs. 75-82. [consulta: 28 de febrer de 2026]. ISSN: Caballero, Miguel; Mackers, Paula; Reig, Oscar; Buxo, Elvira; Navarrete, Pilar; Blanch, Jose L; Grau, Juan J (2017). The Role of Audiometry prior to High-Dose Cisplatin in Patients with Head and Neck Cancer.. Oncology, 93(2), 75-82. DOI: 10.1159/000468522. [Disponible a: https://hdl.handle.net/2445/227589]