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vanveldhoven2017_2826.pdf (2.62 MB)

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2017-11

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cc by (c) Veldhoven et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/118789

Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study

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http://dx.doi.org/10.1016/j.envint.2017.11.017

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BACKGROUND: Exposure to disinfection by-products (DBPs) in drinking water and chlorinated swimming pools are associated with adverse health outcomes, but biological mechanisms remain poorly understood. OBJECTIVES: Evaluate short-term changes in metabolic profiles in response to DBP exposure while swimming in a chlorinated pool. MATERIALS AND METHODS: The PISCINA-II study (EXPOsOMICS project) includes 60 volunteers swimming 40min in an indoor pool. Levels of most common DBPs were measured in water and in exhaled breath before and after swimming. Blood samples, collected before and 2h after swimming, were used for metabolic profiling by liquid-chromatography coupled to high-resolution mass-spectrometry. Metabolome-wide association between DBP exposures and each metabolic feature was evaluated using multivariate normal (MVN) models. Sensitivity analyses and compound annotation were conducted. RESULTS: Exposure levels of all DBPs in exhaled breath were higher after the experiment. A total of 6,471 metabolic features were detected and 293 features were associated with at least one DBP in exhaled breath following Bonferroni correction. A total of 333 metabolic features were associated to at least one DBP measured in water or urine. Uptake of DBPs and physical activity were strongly correlated and mutual adjustment reduced the number of statistically significant associations. From the 293 features, 20 could be identified corresponding to 13 metabolites including compounds in the tryptophan metabolism pathway. CONCLUSION: Our study identified numerous molecular changes following a swim in a chlorinated pool. While we could not explicitly evaluate which experiment-related factors induced these associations, molecular characterization highlighted metabolic features associated with exposure changes during swimming.

Matèries

Aigua potable, Clor, Salut, Piscines

Matèries (anglès)

Drinking water, Chlorine, Health, Swimming pools

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Articles publicats en revistes (ISGlobal)
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

VELDHOVEN, Karin van, KESKI-RAHKONEN, Pekka, BARUPAL, Dinesh kumar, VILLANUEVA, Cristina m., FONT RIBERA, Laia, SCALBERT, Augustin, BODINIER, Barbara, GRIMALT OBRADOR, Joan, ZWIENER, Christian, VLAANDEREN, Jelle, PORTENGEN, Lützen, VERMEULEN, Roel c. h., VINEIS, Paolo, CHADEAU-HYAM, Marc, KOGEVINAS, Manolis. Effects of exposure to water disinfection by-products in a
                swimming pool: A metabolome-wide association study. _Environment International_. 2017. Vol. 111, pàgs. 60-70. [consulta: 23 de gener de 2026]. ISSN: 0160-4120. [Disponible a: https://hdl.handle.net/2445/118789]

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