Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Fitxers

ofaf704.pdf (647.91 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2025-11-26

Llicència de publicació

cc-by-nc-nd (c) De la Villa, Sofía et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226920

Analysis of Clinical Subphenotypes in Methicillin-Resistant Staphylococcus aureus Bacteremia: A Post Hoc Analysis of the MRSA-GEIRAS-SEIMC Study

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1093/ofid/ofaf704

Resum

Background. We aimed to identify and evaluate clinical subphenotypes in a cohort of patients with methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) and to assess their association with all-cause 90-day mortality. Methods. This post hoc analysis of the MRSA-GEIRAS-SEIMC study was conducted across 15 Spanish hospitals. MRSAB in adult patients from 2019 to 2022 were included. Clinical subphenotypes were identified using a combination of principal component analysis and latent class analysis based on age, sex, comorbidities, SOFA score, creatinine levels, metastatic foci, source, and acquisition. The 90-day mortality associated with each subphenotype was estimated using the Kaplan-Meier method. Cox regression was performed to assess the risk of death. Results. A total of 419 MRSAB were included. Four distinct subphenotypes were identified: S1 was associated with younger age, community acquisition, and unknown or skin and soft-tissue infection source; S2 was associated with older age, female sex, high burden of comorbidities, and healthcare-related acquisition; S3 was linked to a catheter source and nosocomial acquisition; and S4 was predominantly associated with the presence of heart valve prostheses, and metastatic foci. Significant differences in all-cause 90-day mortality were observed across subphenotypes: 20.0% in S1, 47.4% in S2, 26.2% in S3, and 35.1% in S4 (P < .01). Cox regression indicated an increased 90-day mortality risk in S2 (HR, 2.98; 95% CI, 1.59-5.56) and S4 (HR, 1.99; 95% CI, 1.16-3.42) compared with S1. Conclusions. We identified 4 distinct clinical subphenotypes of MRSAB associated with prognostic outcomes. Further investigation is needed to implement them into clinical practice. [GRAPHICS]

Matèries

Infeccions per estafilococs, Malalties bacterianes, Estreptomicina

Matèries (anglès)

Staphylococcal infections, Bacterial diseases, Streptomycin

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

Citació

VILLA, Sofía de la, et al. Analysis of Clinical Subphenotypes in Methicillin-Resistant Staphylococcus aureus Bacteremia: A Post Hoc Analysis of the MRSA-GEIRAS-SEIMC Study. Open Forum Infectious Diseases. 2025. Vol. 12, num. 12, pags. ofaf704. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/226920

Exportar metadades

JSON - METS

Compartir registre