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2016-01-04

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cc-by (c) Montull, Beatriz et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/105203

Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia

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https://doi.org/10.1371/journal.pone.0145929

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Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospi- talized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age ( > 65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07 - 1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50 - 2.04) and renal disease (OR, 1.57; 95% CI, 1.21 - 2.03), whereas prior antibiotic treat- ment was a protective factor (OR, 0.62; 95% CI, 0.52 - 0.73). Bacteremia (OR, 1.37; 95% CI, 1.05 - 1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31 - 1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10 - 2.49) were associated with severe sepsis CAP. Conclusions CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.

Matèries

Septicèmia, Malalties pulmonars obstructives cròniques, Pneumònia, Antibiòtics

Matèries (anglès)

Septicemia, Chronic obstructive pulmonary diseases, Pneumonia, Antibiotics

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

MONTULL, Beatriz, MENÉNDEZ, Rosario, TORRES MARTÍ, Antoni, REYES, Soledad, MÉNDEZ, Raúl, ZALACAÍN, Rafael, CAPELASTEGUI, Alberto, RAJAS, Olga, BORDERÍAS, Luis, MARTÍN VILLASCLARAS, Juan, BELLO, Salvador, ALFAGEME, Inmaculada, RODRÍGUEZ DE CASTRO, Felipe, RELLO CONDOMINES, Jordi, MOLINOS, Luis, RUIZ MANZANO, Juan. Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia. _PLoS One_. 2016. Vol. 11, núm. 1, pàgs. e0145929. [consulta: 23 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/105203]

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