Fine-tuning the [Pi]-[Pi]. Aromatic interactions in peptides: somatostatin analogues containing mesityl alanine

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dc.contributor.authorMartín-Gago, Pablo
dc.contributor.authorGomez-Caminals, Marc
dc.contributor.authorRamón, Rosario
dc.contributor.authorVerdaguer i Espaulella, Xavier
dc.contributor.authorMartin-Malpartida, Pau
dc.contributor.authorAragón Altarriba, Eric
dc.contributor.authorFernández-Carneado, Jimena
dc.contributor.authorPonsati, Berta
dc.contributor.authorLópez-Ruiz, Pilar
dc.contributor.authorCortes, María Alicia
dc.contributor.authorColás, Begoña
dc.contributor.authorMacías Hernández, María J.
dc.contributor.authorRiera i Escalé, Antoni
dc.date.accessioned2021-05-07T10:41:07Z
dc.date.available2021-05-07T10:41:07Z
dc.date.issued2012-02
dc.date.updated2021-05-07T10:41:07Z
dc.description.abstractGoing through the motions: Somatostatin analogues having greater conformational rigidity than somatostatin have been prepared by substituting Phe residues in the native sequence with mesityl alanine (Msa; see structure). The analogues show high affinity for SSTR receptors, thus showing that fine‐tuning of noncovalent interactions between amino acid side chains can modulate peptide affinity and selectivity.
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec606258
dc.identifier.issn1433-7851
dc.identifier.urihttps://hdl.handle.net/2445/177099
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/anie.201106406
dc.relation.ispartofAngewandte Chemie-International Edition, 2012, vol. 51, num. 8, p. 1820-1825
dc.relation.urihttps://doi.org/10.1002/anie.201106406
dc.rights(c) Wiley-VCH, 2012
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationSomatostatina
dc.subject.classificationPèptids
dc.subject.otherSomatostatin
dc.subject.otherPeptides
dc.titleFine-tuning the [Pi]-[Pi]. Aromatic interactions in peptides: somatostatin analogues containing mesityl alanine
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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