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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/179068
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
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Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis.
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MORALES, Paula, et al. Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**. Chemistry-A European Journal. 2020. Vol. 26, num. 68, pags. 15839-15842. ISSN 0947-6539. [consulted: 8 of October of 2026]. Available at: https://hdl.handle.net/2445/179068