Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**

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dc.contributor.authorMorales, Paula
dc.contributor.authorNavarro Brugal, Gemma
dc.contributor.authorGómez-Autet, Marc
dc.contributor.authorRedondo, Laura
dc.contributor.authorFernández-Ruiz, Javier
dc.contributor.authorPérez-Benito, Laura
dc.contributor.authorCordomí, Arnau
dc.contributor.authorPardo, Leonardo
dc.contributor.authorFranco Fernández, Rafael
dc.contributor.authorJagerovic, Nadine
dc.date.accessioned2021-07-15T05:49:44Z
dc.date.available2021-11-09T06:10:21Z
dc.date.issued2020-11-09
dc.date.updated2021-07-15T05:49:45Z
dc.description.abstractSingle chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec709677
dc.identifier.issn0947-6539
dc.identifier.pmid32794211
dc.identifier.urihttps://hdl.handle.net/2445/179068
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/chem.202003389
dc.relation.ispartofChemistry-A European Journal, 2020, vol. 26, num. 68, p. 15839-15842
dc.relation.urihttps://doi.org/10.1002/chem.202003389
dc.rights(c) Wiley-VCH, 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject.classificationReceptors cel·lulars
dc.subject.classificationProteïnes G
dc.subject.classificationInteracció cel·lular
dc.subject.classificationCànnabis
dc.subject.otherCell receptors
dc.subject.otherG Proteins
dc.subject.otherCell interaction
dc.subject.otherCannabis
dc.titleDiscovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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