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2020-02-01

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cc by (c) Diaz Peña et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173268

Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer

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https://doi.org/10.3390/cells9020514

Resum

Natural killer cells (NK cells) play a major role in the immune response to cancer. An important element of NK target recognition is the binding of human leucocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Colorectal carcinoma (CRC) is one of the most common types of inflammation-based cancer. The purpose of the present study was to investigate the presence of KIR genes and HLA class I and II alleles in 1074 CRC patients and 1272 controls. We imputed data from single-nucleotide polymorphism (SNP) Illumina OncoArray to identify associations at HLA (HLA-A, B, C, DPB1, DQA1, DQB1, and DRB1) and KIRs (HIBAG and KIR*IMP, respectively). For association analysis, we used PLINK (v1.9), the PyHLA software, and R version 3.4.0. Only three SNP markers showed suggestive associations (p < 10(-3); rs16896742, rs28367832, and rs9277952). The frequency of KIR2DS3 was significantly increased in the CRC patients compared to healthy controls (p < 0.005). Our results suggest that the implication of NK cells in CRC may not act through allele combinations in KIR and HLA genes. Much larger studies in ethnically homogeneous populations are needed to rule out the possible role of allelic combinations in KIR and HLA genes in CRC risk.

Matèries

Càncer colorectal, Cèl·lules K

Matèries (anglès)

Colorectal cancer, Killer cells

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

DIAZ PEÑA, Roberto, MONDELO MACÍA, Patricia, TORRE, Antonio josé molina de la, SANZ PAMPLONA, Rebeca, MORENO AGUADO, Víctor, MARTÍN SÁNCHEZ, Vicente. Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer. _Cells_. 2020. Vol. 9, núm. 2. [consulta: 15 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/173268]

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