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2014-02-04

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cc-by-nc-sa (c) Bujanda, Luis et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/122159

Effect of oral anticoagulants on the outcome of faecal immunochemical test

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https://doi.org/10.1038/bjc.2014.38

Abstract

Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend ¼ 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P ¼ 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P ¼ 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

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Càncer colorectal, Anticoagulants (Medicina), Immunoquímica, Colonoscòpia, Estudi de casos

Subject (English)

Colorectal cancer, Anticoagulants (Medicine), Immunochemistry, Colonoscopy, Case studies

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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BUJANDA, Luis, et al. Effect of oral anticoagulants on the outcome of faecal immunochemical test. British Journal of Cancer. 2014. Vol. 110, num. 5, pags. 1334-1337. ISSN 0007-0920. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/122159

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