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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/215161
Estudi de l’efecte del consum matern d’emulgents presents en aliments ultra-processats en la salut metabòlica i neuropsicològica de la descendència
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[cat] L’estil de vida moderna està associat a un major consum d’aliments ultra-processats (UPF) degut a la seva practicitat i palatabilitat. El consum d’emulgents, un dels principals additius dels UPF, s’ha relacionat relacionat amb la inflamació intestinal, disbiosi de la microbiota, adipositat i obesitat. Uns hàbits nutricionals materns desequilibrats durant l’etapa embrionària i perinatal alteren la salut metabòlica de la descendència a llarg termini, augmentant el risc d’obesitat i comorbiditats associades. No obstant, encara es desconeix si el consum matern d’emulgents influeix en la programació fetal de la descendència. En aquest estudi, mostrem que, en ratolins, el consum matern d’emulgents (1% carboximetilcel·lulosa sòdica (CMC) i 1% polisorbat 80 (P80) en aigua), durant el període de gestació i lactància, altera el desenvolupament hipotalàmic dels centres que regulen el balanç energètic de la descendència, condueix a disfuncions metabòliques, dèficits cognitiu i indueix conductes similars al trastorn d’ansietat depenent del sexe. Aquests resultats donen suport a la idea de que un consum matern d’emulgents, additiu comú en els UPFs, causa una mala programació, tot i que lleu, en la salut metabòlica i neuro-psicològica de la descendència. L’estudi vol ser un reclam a tenir consciencia nutricional durant el període de gestació i lactància.
[eng] Modern lifestyle is associated with a major consumption of ultra-processed foods (UPF) due to their practicality and palatability. The ingestion of emulsifiers, a main additive in UPFs, has been related to gut inflammation, microbiota dysbiosis, adiposity and obesity. Maternal unbalanced nutritional habits during embryonic and perinatal stages perturb offspring’s long–term metabolic health, thus increasing obesity and associated comorbidity risk. However, whether maternal emulsifier consumption influences developmental programming in the offspring remains unknown. Here, we show that, in mice, maternal consumption of dietary emulsifiers (1% carboxymethyl cellulose (CMC) and 1% polysorbate 80 (P80) in drinking water), during gestation and lactation, perturbs the development of hypothalamic energy balance regulation centers of the progeny, leads to metabolic impairments, cognition deficits, and induces anxiety–like traits in a sex–specific manner. Our findings support the notion that maternal consumption of emulsifiers, common additives of UPFs, causes mild metabolic and neuropsychological malprogramming in the progeny. Our data call for nutritional advice during gestation and lactation.
[eng] Modern lifestyle is associated with a major consumption of ultra-processed foods (UPF) due to their practicality and palatability. The ingestion of emulsifiers, a main additive in UPFs, has been related to gut inflammation, microbiota dysbiosis, adiposity and obesity. Maternal unbalanced nutritional habits during embryonic and perinatal stages perturb offspring’s long–term metabolic health, thus increasing obesity and associated comorbidity risk. However, whether maternal emulsifier consumption influences developmental programming in the offspring remains unknown. Here, we show that, in mice, maternal consumption of dietary emulsifiers (1% carboxymethyl cellulose (CMC) and 1% polysorbate 80 (P80) in drinking water), during gestation and lactation, perturbs the development of hypothalamic energy balance regulation centers of the progeny, leads to metabolic impairments, cognition deficits, and induces anxiety–like traits in a sex–specific manner. Our findings support the notion that maternal consumption of emulsifiers, common additives of UPFs, causes mild metabolic and neuropsychological malprogramming in the progeny. Our data call for nutritional advice during gestation and lactation.
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MILÀ GUASCH, Maria. Estudi de l’efecte del consum matern d’emulgents presents en aliments ultra-processats en la salut metabòlica i neuropsicològica de la descendència. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/215161