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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/194308
Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium.
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t is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout induced senescence, therefore suggesting that a mitochondrial superoxide takes part in inducing senescence. Taken together, these analyses reveal extremely low levels of cellular senescence and senescence-associated phenotypes in the esophageal epithelium, as well as a critical role for Myc in self-renewal of basal cells in this organ. This provides new avenues for studying and understanding the links between stemness and resistance to cellular senescence.
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HISHIDA, Tomoaki, et al. Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. Frontiers In Cell And Developmental Biology. 2022. Vol. 10. ISSN 2296-634X. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/194308