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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/194308
Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium.
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t is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout induced senescence, therefore suggesting that a mitochondrial superoxide takes part in inducing senescence. Taken together, these analyses reveal extremely low levels of cellular senescence and senescence-associated phenotypes in the esophageal epithelium, as well as a critical role for Myc in self-renewal of basal cells in this organ. This provides new avenues for studying and understanding the links between stemness and resistance to cellular senescence.
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HISHIDA, Tomoaki, VAZQUEZ-FERRER, Eric, HISHIDA NOZAKI, Yuriko, TAKEMOTO, Yuto, HATANAKA, Fumiyuki, YOSHIDA, Kei, PRIETO, Javier, SAHU, Sanjeeb kumar, TAKAHASHI, Yuta, REDDY, Pradeep, O'KEEFE, David d., RODRIGUEZ ESTEBAN, Concepción, KNOEPFLER, Paul s., NUÑEZ DELICADO, Estrella, CASTELLS GARANGOU, Antoni, CAMPISTOL PLANA, Josep m., KATO, Ryuji, NAKAGAWA, Hiroshi, IZPISÚA BELMONTE, Juan carlos. Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium.. _Frontiers In Cell And Developmental Biology_. 2022. Vol. 10. [consulta: 14 de gener de 2026]. ISSN: 2296-634X. [Disponible a: https://hdl.handle.net/2445/194308]