Synthesis and prelimnary biological evaluation of 1,3,5-triazine amino acid derivatives to study their MAO inhibitors

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dc.contributor.authorKhattab, Sherine N.
dc.contributor.authorKhalil, Hosam H.
dc.contributor.authorBekhit, Adnan A.
dc.contributor.authorMokbel Abd El-Rahman, Mohamed
dc.contributor.authorAyman El-Faham, Ayman
dc.contributor.authorAlbericio Palomera, Fernando
dc.date.accessioned2020-03-03T16:13:25Z
dc.date.available2020-03-03T16:13:25Z
dc.date.issued2015-09-02
dc.date.updated2020-03-03T16:13:26Z
dc.description.abstractThree series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.
dc.format.extent13 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec666975
dc.identifier.issn1420-3049
dc.identifier.pmid26364629
dc.identifier.urihttps://hdl.handle.net/2445/151831
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/molecules200915976
dc.relation.ispartofMolecules, 2015, vol. 20, num. 9, p. 15976-15988
dc.relation.urihttps://doi.org/10.3390/molecules200915976
dc.rightscc-by (c) Khattab, Sherine N. et al., 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationAminoàcids
dc.subject.classificationHormones
dc.subject.otherAmino acids
dc.subject.otherHormones
dc.titleSynthesis and prelimnary biological evaluation of 1,3,5-triazine amino acid derivatives to study their MAO inhibitors
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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