Miniatura

Fitxers

cancers-17-02275-v2.pdf (422.54 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2025-07-08

Llicència de publicació

cc-by (c) Katzke, Verena et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222846

Sex disparities and female reproductive and hormonal factors associated with risk of pancreatic cancer in the european prospective investigation into cancer and nutrition (EPIC) cohort

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/cancers17142275

Resum

Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to <= 5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus <= 2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect.

Matèries

Càncer de pàncrees, Factors sexuals en les malalties

Matèries (anglès)

Pancreas cancer, Sex factors in disease

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

KATZKE, Verena, DUTTA, Srimanti, RASOKAT, Anna, ARCHIBUGI, Livia, CAPURSO, Gabriele, PEDUZZI, Giulia, GENTILUOMO, Manuel, CANZIAN, Federico, ERIKSEN, Anne kirstine, TJØNNELAND, Anne, DAHM, Christina c., TRUONG, Thérèse, CANONICO, Marianne, LAOUALI, Nasser, SCHULZE, Matthias b., TUMINO, Rosario, MASALA, Giovanna, AGNOLI, Claudia, DANSERO, Lucia, PANICO, Salvatore, CROUS BOU, Marta, MOLINA MONTES, Esther, DORRONSORO, Ane, CHIRLAQUE, María dolores, GUEVARA, Marcela, BUTT, Salma tunå, SUND, Malin, CHRISTAKOUDI, Sofia, AGLAGO, Elom k., WEIDERPASS, Elisabete, GUNTER, Marc j., CAMPA, Daniele, KAAKS, Rudolf. Sex disparities and female reproductive and hormonal factors associated with risk of pancreatic cancer in the european prospective investigation into cancer and nutrition (EPIC) cohort. _Cancers_. 2025. Vol. 17, núm. 14, pàgs. 2275. [consulta: 25 de febrer de 2026]. ISSN: 2072-6694. [Disponible a: https://hdl.handle.net/2445/222846]

Exportar metadades

JSON - METS

Compartir registre