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2021-03-01

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cc-by-nc (c) Gutiérrez Villanueva, Andrea et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184342

Mural Endocarditis: The GAMES Registry Series and Review of the Literature

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https://doi.org/10.1007/s40121-021-00490-y

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Introduction: Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis. Methods: Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series. Results: Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p < 0.01). Transplantation (18.5% versus 1.6% VIE and 2% DIE, p < 0.01), hemodialysis (18.5% versus 4.3% VIE and 4.4% DIE, p = 0.006), catheter source (59.3% versus 9.7% VIE and 8.8% DIE, p < 0.01) and Candida etiology (22.2% versus 2% DIE and 1.2% VIE, p < 0.01) were more common in MIE, whereas the Charlson Index was lower (4 versus 5 in non-MIE, p = 0.006). Mortality was similar. MIE from the literature shared many characteristics with MIE from GAMES, although patients were younger (45 years vs. 56 years, p < 0.001), the Charlson Index was lower (1.3 vs. 4.3, p = 0.0001), catheter source was less common (13.9% vs. 59.3%) and there were more IVDUs (25% vs. 3.7%). S. aureus was the most frequent microorganism (50%, p = 0.035). Systemic complications were more common but mortality was similar. Conclusion: MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.

Matèries

Endocarditis, Infeccions, Malalts hospitalitzats

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Endocarditis, Infections, Hospital patients

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

GUTIÉRREZ VILLANUEVA, Andrea, MUÑOZ, Patricia, DELGADO MONTERO, Antonio, OLMEDO SAMPERIO, María, ALARCÓN, Aristides de, GUTIÉRREZ CARRETERO, Encarnación, ZARAUZA, Jesús, GARCÍA I PARES, Delia, GOENAGA SÁNCHEZ, Miguel ángel, OJEDA BURGOS, Guillermo, GOIKOETXEA AGIRRE, Ane josune, REGUERA IGLESIAS, José m., RAMOS, Antonio, FERNÁNDEZ CRUZ, Ana, Spanish Collaboration on Endocarditis, Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES). Mural Endocarditis: The GAMES Registry Series and Review of the Literature. _Infectious Diseases and Therapy_. 2021. Vol. 10, núm. 4, pàgs. 2749-2764. [consulta: 26 de febrer de 2026]. ISSN: 2193-8229. [Disponible a: https://hdl.handle.net/2445/184342]

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