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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180368
Risk of Developing Epilepsy after Autoimmune Encephalitis
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Background: Acute symptomatic seizures (ASS) are a common manifestation of autoimmune encephalitis (AE), but the risk of developing epilepsy as a sequela of AE remains unknown, and factors predisposing the development of epilepsy have not been fully identified. Objective: To assess the risk of developing epilepsy in AE and study related risk factors. Materials and methods: This was a retrospective single centre study including patients diagnosed with AE according to criteria described by Graus et al., with a minimum follow-up of 12 months after AE resolution. The sample was divided according to whether patients developed epilepsy or not. Results: A total of 19 patients were included; 3 (15.8%) had AE with intracellular antibodies, 9 (47.4%) with extracellular antibodies, and 7 (36.8%) were seronegative. During follow-up, 3 patients (15.8%) died, 4 (21.1%) presented relapses of AE, and 11 (57.89%) developed epilepsy. There was a significant association between the development of epilepsy and the presence of hippocampal atrophy in control brain magnetic resonance imaging (MRI) (p = 0.037), interictal epileptiform discharges (IED) on control electroencephalogram (EEG) (p = 0.045), and immunotherapy delay (p = 0.016). Conclusions: Hippocampal atrophy in neuroimaging, IED on EEG during follow-up, and immunotherapy delay could be predictors of the development of epilepsy in patients with AE.
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GIFREU, Ariadna, FALIP, Mercè, SALA PADRÓ, Jacint, MONGAY, Neus, MORANDEIRA-REGO, Francisco, CAMINS, Àngels, NAVAL BAUDIN, Pablo, VECIANA DE LAS HERAS, Misericordia, FERNÁNDEZ, Montserrat, PEDRO, Jordi, GARCIA PARRA, Belia, ARROYO, Pablo, SIMÓ, Marta. Risk of Developing Epilepsy after Autoimmune Encephalitis. _Brain Sciences_. 2021. Vol. 11, núm. 9, pàgs. 1182. [consulta: 25 de febrer de 2026]. ISSN: 2076-3425. [Disponible a: https://hdl.handle.net/2445/180368]