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2009-12-24

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cc-by (c) Fellay, J. et al., 2009
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/44169

Common genetic variation and the control of HIV-1 in humans

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http://dx.doi.org/10.1371/journal.pgen.1000791

Resum

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Matèries

Genètica molecular, VIH (Virus)

Matèries (anglès)

Molecular genetics, HIV (Viruses)

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Articles publicats en revistes (Medicina)

Citació

FELLAY, Jacques, GE, Dongliang, SHIANNA, Kevin v., COLOMBO, Sara, LEDERGERBER, Bruno, CIRULLI, Elisabeth t., URBAN, Thomas j., ZHANG, Kunlin, GUMBS, Curtis e., SMITH, Jason p., CASTAGNA, Antonella, COZZI-LEPRI, Alessandro, DE LUCA, Andrea, EASTERBROOK, Philippa, GÜNTHARD, Huldrych f., MALLAL, Simon, MUSSINI, Cristina, DALMAU, Judith, MARTÍNEZ PICADO, Francisco javier, MIRÓ MEDA, José m. (josé maría), OBEL, Niels, WOLINSKY, Steven, MARTINSON, Jeremy j, DETELS, Roger, MARGOLICK, Joseph b., JACOBSON, Lisa p., DESCOMBES, Patrick, ANTONARAKIS, Stylianos e., BECKMANN, Jacques, O'BRIEN, Stephen j., LETVIN, Norman l., MCMICHAEL, Andrew j., HAYNES, Barton f., CARRINGTON, Mary, FENG, Sheng, TELENTI, Amalio, GOLDSTEIN, David b.. Common genetic variation and the control of HIV-1 in humans. _PLoS Genetics_. 2009. Vol. 5, núm. 12, pàgs. e1000791. [consulta: 20 de gener de 2026]. ISSN: 1553-7390. [Disponible a: https://hdl.handle.net/2445/44169]

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