Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173279
Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: There is no established insulin regimen in T2DM patients receiving parenteral nutrition. Aims: To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN. Design: Prospective, open-label, multicenter, clinical trial on adult inpatients with type 2 diabetes on a non-critical setting with indication for TPN. Patients were randomized on one of these two regimens: 100% of RI on TPN or 50% of Regular insulin added to TPN bag and 50% subcutaneous Gl. Data were analyzed according to intention-to-treat principle. Results: 81 patients were on RI and 80 on GI. No differences were observed in neither average total daily dose of insulin, programmed or correction, nor in capillary mean blood glucose during TPN infusion (165.3 +/- 35.4 in RI vs 172.5 +/- 43.6 mg/dL in GI; p = 0.25). Mean capillary glucose was significantly lower in the GI group within two days after TPN interruption (160.3 +/- 45.1 in RI vs 141.7 +/- 43.8 mg/dL in GI; p = 0.024). The percentage of capillary glucose above 180 mg/dL was similar in both groups. The rate of capillary glucose <= 70 mg/dL, the number of hypoglycemic episodes per 100 days of TPN, and the percentage of patients with non-severe hypoglycemia were significantly higher on GI group. No severe hypoglycemia was detected. No differences were observed in length of stay, infectious complications, or hospital mortality. Conclusion: Effectiveness of both regimens was similar. GI group achieved better metabolic control after TPN interruption but non-severe hypoglycemia rate was higher in the GI group. (C) 2019 The Author(s). Published by Elsevier Ltd.
Citació
Citació
OLVEIRA, Gabriel, ABUÍN, Jose, LÓPEZ, Rafael, HERRANZ, Sandra, GARCÍA ALMEIDA, Jose m., GARCÍA MALPARTIDA, Katherine, FERRER, Mercedes, CANCER MINCHOT, Emilia, LUENGO PÉREZ, Luis m., ÁLVAREZ, Julia, ARAGÓN VALERA, Carmen, OCÓN, María j., GARCÍA MANZANARES, Álvaro, BRETÓN LESMES, Irene, SERRANO AGUAYO, Pilar, PÉREZ FERRE, Natalia, LÓPEZ GÓMEZ, Juan josé, OLIVARES, Josefina, ARRAIZA IRIGOYEN, Carmen, TEJERA, Cristina, MARTIN, Jorge d., GARCÍA, Sara, ABAD, Angel l., ALHAMBRA, María r., ZUGASTI MURILLO, Ana, PARRA, Juan, TORREJÓN, Sara, TAPIA, María j.. Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial. _Clinical Nutrition_. 2020. Vol. 39, núm. 2, pàgs. 388-394. [consulta: 26 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/173279]