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2020-06

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Domini públic / Public domain
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/196032

Failures of 13-Valent Conjugated Pneumococcal Vaccine in Age-Appropriately Vaccinated Children 2-59 Months of Age, Spain

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https://doi.org/10.3201/eid2606.190951

Abstract

Vaccination with the 13-valent conjugated pneumococcal disease (PCV13) has reduced invasive pneumococcal disease (IPD), but there have been reports of vaccine failures. We performed a prospective study in children aged 2-59 months who received diagnoses of IPD during January 2012-June 2016 in 3 pediatric hospitals in Catalonia, Spain, a region with a PCV13 vaccination coverage of 63%. We analyzed patients who had been age-appropriately vaccinated but who developed IPD caused by PCV13 serotypes. We detected 24 vaccine failure cases. The serotypes involved were 3 (16 cases); 19A (5 cases); and 1, 6B, and 14 (1 case each). Cases were associated with children without underlying conditions, with complicated pneumonia (OR 6.65, 95% CI 1.91-23.21), and with diagnosis by PCR (OR 5.18, 95% CI 1.84-14.59). Vaccination coverage should be increased to reduce the circulation of vaccine serotypes. Continuous surveillance of cases of IPD using both culture and PCR to characterize vaccine failures is necessary.

Subject

Reacció en cadena de la polimerasa, Espanya, Pneumococs, Vacunes antibacterianes, Pneumònia, Infeccions respiratòries, Infeccions per estreptococs, Vacunació dels infants

Subject (English)

Polymerase chain reaction, Spain, Streptococcus pneumonia, Bacterial vaccines, Pneumonia, Respiratory infections, Streptococcal infections, Vaccination of children

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Medicina)

Citation

HERNÁNDEZ, Sergi, et al. Failures of 13-Valent Conjugated Pneumococcal Vaccine in Age-Appropriately Vaccinated Children 2-59 Months of Age, Spain. Emerging Infectious Diseases. 2020. Vol. 26, num. 6, pags. 1147-1155. ISSN 1080-6040. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/196032

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