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Pertussis vaccination during pregnancy: Antibody persistence in infants
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Abstract
Maternal pertussis vaccination is associated with higher levels
of pertussis antibodies at birth. We assessed the persistence of
pertussis antibodies until primary vaccination in infants whose
mothers received Tdap (tetanus, diphtheria, acellular pertussis)
vaccine during pregnancy. Infants were born at the Hospital
Clinic of Barcelona (Spain) in November 2014. Anti-PT IgG was
determined by ELISA at delivery, between the first and second
month of life, and estimated at 2months of age. The study
included 37 infants whose mothers received Tdap between 21 and
38weeks of gestation. Infants presented a decline in GMC of
anti-PT IgG between peripartum and follow-up levels, 52.7 (95%
CI 34.7-80.2) versus 7.5 (95% CI 4.2-13.3) at 2months of age
(p<0.001). The median half-life of maternal antibodies was
47days. More than half (51.4%) the infants presented detectable
anti-PT IgG before the start of primary infant vaccination.
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VILAJELIU, Alba, et al. Pertussis vaccination during pregnancy: Antibody persistence in
infants. Vaccine. 2016. Vol. 34, num. 33, pags. 3719-22. ISSN 0264-410X. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/101651