Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

714193.pdf (1.27 MB)

Document type

Article

Version

Published version

Publication date

2021-09-06

Publication license

cc by-nc-nd (c) Casellas-Díaz, Sergi et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/182364

Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.15252/embr.202051954

Abstract

Mfn2 is a mitochondrial fusion protein with bioenergetic functionsimplicated in the pathophysiology of neuronal and metabolicdisorders. Understanding the bioenergetic mechanism of Mfn2may aid in designing therapeutic approaches for these disorders.Here we show using endoplasmic reticulum (ER) or mitochondria-targeted Mfn2 that Mfn2 stimulation of the mitochondrial meta-bolism requires its localization in the ER, which is independent ofits fusion function. ER-located Mfn2 interacts with mitochondrialMfn1/2 to tether the ER and mitochondria together, allowing Ca2+transfer from the ER to mitochondria to enhance mitochondrialbioenergetics. The physiological relevance of these findings isshown during neurite outgrowth, when there is an increase inMfn2-dependent ER-mitochondria contact that is necessary forcorrect neuronal arbor growth. Reduced neuritic growth in Mfn2KO neurons is recovered by the expression of ER-targeted Mfn2 oran artificial ER-mitochondria tether, indicating that manipulationof ER-mitochondria contacts could be used to treat pathologicconditions involving Mfn2.

Subject

Mitocondris, Proteïnes, Metabolisme energètic, Trastorns del metabolisme, Fisiologia patològica

Subject (English)

Mitochondria, Proteins, Energy metabolism, Disorders of metabolism, Pathological physiology

Citation

Collections

Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citation

CASELLAS DÍAZ, Sergi, et al. Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development. EMBO Reports. 2021. Vol. 22, num. 9, pags. 1-20. ISSN 1469-221X. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/182364

Export metadata

JSON - METS

Share record