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2020-11-18

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cc-by (c) Dueñas, Nuria et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172568

Assessing effectiveness of colonic and gynecological risk reducing surgery in lynch syndrome individuals

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https://doi.org/10.3390/cancers12113419

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Background: Colorectal (CRC) and endometrial cancer (EC) are the most common types of cancer in Lynch syndrome (LS). Risk reducing surgeries (RRS) might impact cancer incidence and mortality. Our objectives were to evaluate cumulative incidences of CRC, gynecological cancer and all-cause mortality after RRS in LS individuals. Methods: retrospective analysis of 976 LS carriers from a single-institution registry. Primary endpoints were cumulative incidence at 75 years of cancer (metachronous CRC in 425 individuals; EC and ovarian cancer (OC) in 531 individuals) and all-cause mortality cumulative incidence, comparing extended (ES) vs. segmental surgery (SS) in the CRC cohort and risk reducing gynecological surgery (RRGS) vs. surveillance in the gynecological cohort. Results: cumulative incidence at 75 years of metachronous CRC was 12.5% vs. 44.7% (p = 0.04) and all-cause mortality cumulative incidence was 38.6% vs. 55.3% (p = 0.31), for ES and SS, respectively. Cumulative, incidence at 75 years was 11.2% vs. 46.3% for EC (p = 0.001) and 0% vs. 12.7% for OC (p N/A) and all-cause mortality cumulative incidence was 0% vs. 52.7% (p N/A), for RRGS vs. surveillance, respectively. Conclusions: RRS in LS reduces the incidence of metachronous CRC and gynecological neoplasms, also indicating a reduction in all-cause mortality cumulative incidence in females undergoing RRGS.

Matèries

Càncer colorectal, Càncer d'endometri, Càncer ginecològic, Càncer d'ovari

Matèries (anglès)

Colorectal cancer, Endometrial cancer, Gynecologic cancer, Ovarian cancer

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Infermeria Fonamental i Clínica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citació

DUEÑAS, Nuria, NAVARRO, Matilde, TEULÉ-VEGA, Àlex, SOLANES, Ares, SALINAS MASDEU, Mònica, IGLESIAS CASALS, Sílvia, MUNTÉ, Elisabet, PONCE I SEBASTIÀ, Jordi, GUARDIOLA, Jordi, KREISLER, Esther, CARBALLAS, Elvira, CUADRADO, Marta, MATIAS-GUIU, Xavier, OSSA, Napoleón de la, LOP, Joan, LÁZARO GARCÍA, Conxi, CAPELLÁ, G. (gabriel), PINEDA RIU, Marta, BRUNET, Joan. Assessing effectiveness of colonic and gynecological risk reducing surgery in lynch syndrome individuals. _Cancers_. 2020. Vol. 12, núm. 11, pàgs. 3419. [consulta: 25 de febrer de 2026]. ISSN: 2072-6694. [Disponible a: https://hdl.handle.net/2445/172568]

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