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2018-01-22

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cc-by (c) Espino Gaurch, Meritxell et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/121010

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss.

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Recurs relacionat

https://doi.org/10.7554/eLife.31511

Resum

Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated that SLC7A8 is expressed in the mouse inner ear and that its ablation resulted in ARHL, due to the damage of different cochlear structures. These findings make SLC7A8 transporter a strong candidate for ARHL in humans. Thus, a screening of a cohort of ARHL patients and controls was carried out revealing several variants in SLC7A8, whose role was further investigated by in vitro functional studies. Significant decreases in SLC7A8 transport activity was detected for patient's variants (p.Val302Ile, p.Arg418His, p.Thr402Met and p.Val460Glu) further supporting a causative role for SLC7A8 in ARHL. Moreover, our preliminary data suggest that a relevant proportion of ARHL cases could be explained by SLC7A8 mutations.

Matèries

Trastorns auditius, Persones grans, Etiologia, Mutació (Biologia)

Matèries (anglès)

Hearing disorders, Older people, Etiology, Mutation (Biology)

Citació

Col·leccions

Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

ESPINO GAURCH, Meritxell, FONT I LLITJÓS, Mariona, MURILLO-CUESTA, Silvia, ERRASTI-MURUGARREN, Ekaitz, CELAYA, Adelaida m., GIROTTO, Giorgia, VUCKOVIC, Dragana, MEZZAVILLA, Massimo, VILCHES, Clara, BODOY I SALVANS, Susanna, SAHÚN, Ignasi, GONZÁLEZ, Laura, PRAT, Esther, ZORZANO OLARTE, Antonio, DIERSSEN, Mara, VARELA-NIETO, Isabel, GASPARINI, Paolo, PALACÍN PRIETO, Manuel, NUNES MARTÍNEZ, Virginia. Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss.. _eLife_. 2018. Vol. 7, núm. e3151. [consulta: 25 de febrer de 2026]. ISSN: 2050-084X. [Disponible a: https://hdl.handle.net/2445/121010]

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