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2026-05-15

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cc-by (c) Casas, M et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230355

Bilateral equalization of synaptic output in olfactory glomeruli of Xenopus tadpoles

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Recurs relacionat

https://doi.org/10.7554/eLife.107710.3

Resum

Odorants stimulate olfactory sensory neurons (OSNs) to create a bilateral sensory map defined by a set of glomeruli present in the left and right olfactory bulbs. Using Xenopus tropicalis tadpoles, we challenged the notion that glomerular activation is exclusively determined ipsilaterally. Glomerular responses evoked by unilateral stimulation were potentiated following transection of the contralateral olfactory nerve. The gain of function was observed as early as 2 hr after injury and faded away with a time constant of 4 days. Potentiation was mediated by the presence of larger and faster calcium transients driving glutamate release from OSN axon terminals. The cause was the reduction of the tonic presynaptic inhibition exerted by dopamine D2 receptors. Inflammatory mediators generated by injury were not involved. These findings reveal the presence of a bilateral modulation of glomerular output driven by dopamine that compensates for imbalances in the number of operative OSNs present in the two olfactory epithelia. Considering that the constant turnover of OSNs is an evolutionarily conserved feature of the olfactory system and determines the innervation of glomeruli, the compensatory mechanism described here may represent a general property of the vertebrate olfactory system to establish an odor map.

Matèries

Xenopus laevis, Neurones sensorials

Matèries (anglès)

Xenopus laevis, Sensory neurons

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

CASAS, Marta, TERNI, Beatrice and LLOBET BERENGUER, Artur. Bilateral equalization of synaptic output in olfactory glomeruli of Xenopus tadpoles. eLife. 2026. Vol. 14. ISSN 2050-084X. [consulted: 27 of August of 2026]. Available at: https://hdl.handle.net/2445/230355

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