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2022-01-03

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cc-by (c) Pires da Rosa, Gilberto et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/186526

The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.

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https://doi.org/10.1186/s13075-021-02702-9

Resum

Background: Seronegative antiphospholipid syndrome (SN-APS) is often defned as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. Nevertheless, the impact of these non-criteria features is still unclear. On a diferent note, the relevance of one single aPL positive determination in patients with APS manifestations is another domain with limited evidence. We aim to compare the course of SN-APS and single-positive aPL (SP-aPL) patients with that of individuals with APS manifesta‑ tions without non-criteria features/aPL positivity (controls). Methods: Retrospective analysis of patients with thrombosis/obstetric morbidity assessed in two European hospi‑ tals between 2005 and 2020. Patients were divided into SN-APS, SP-aPL, and control groups. Clinical characteristics, comorbidities, and therapies were compared. Results: A total of 82 patients were included in the SN-APS group, 88 in the SP-aPL group, and 185 in the control group. In Cox regression model, SN-APS displayed more thrombosis recurrence than controls (HR 3.8, 95% CI 2.2-6.5, p<0.001) even when adjusting for the presence of hereditary thrombophilia, systemic lupus erythematosus, or con‑ traceptive hormonal treatment. In SP-aPL, the diference in thrombosis recurrence did not reach statistical signifcance (p=0.078). Indefnite anticoagulation (p<0.001 and p=0.008, respectively) and vitamin K antagonist (VKA) use (p<0.001 in both cases) were more common in SN-APS/SP-aPL. Conclusion: SN-APS displayed more thrombosis recurrence, indefnite anticoagulation, and VKA use than controls without non-criteria manifestations. The presence of such features in patients with thrombosis and negative aPL may negatively impact their clinical course. Keywords: Antiphospholipid syndrome, Antiphospholipid antibodies, Seronegative, Single positive, Non-criteria manifestations

Matèries

Malalties autoimmunitàries, Síndrome antifosfolipídica, Autoanticossos, Lupus eritematós, Embaràs

Matèries (anglès)

Autoimmune diseases, Antiphospholipid syndrome, Autoantibodies, Lupus erythematosus, Pregnancy

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

PIRES DA ROSA, Gilberto, et al. The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study. Arthritis Research & Therapy. 2022. Vol. 24, num. 1, pags. 9. ISSN 1478-6362. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/186526

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