Miniatura

Fitxers

720793.pdf (279.94 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-05-06

Llicència de publicació

cc-by (c) Del Bo, Cristian et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184402

Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/antiox10050730

Resum

Abstract The use of DNA damage as marker of oxidative stress, metabolic dysfunction and age-related diseases is debated. The present study aimed at assessing the level of DNA damage (evaluated as DNA strand-breaks, endogenous and oxidatively-induced DNA damage) in a group of older subjects with intestinal permeability enrolled within the MaPLE (Gut and Blood Microbiomics for Studying the Effect of a Polyphenol-Rich Dietary Pattern on Intestinal Permeability in the Elderly) intervention trial, to evaluate its association with clinical, metabolic and dietary markers. DNA damage in peripheral blood mononuclear cells was assessed by the comet assay in 49 older subjects participating in the study. Clinical and metabolic markers, markers of inflammation, vascular function and intestinal permeability were determined in serum. Food intake was estimated by weighted food diaries. On the whole, a trend towards higher levels of DNA damage was observed in men compared to women (p = 0.071). A positive association between DNA damage and clinical/metabolic markers (e.g., uric acid, lipid profile) and an inverse association with dietary markers (e.g., vitamin C, E, B6, folates) were found and differed based on sex. By considering the importance of DNA stability during aging, the results obtained on sex differences and the potential role of dietary and metabolic factors on DNA damage underline the need for further investigations in a larger group of older adults to confirm the associations found and to promote preventive strategies.

Matèries

Polifenols, Persones grans, Envelliment

Matèries (anglès)

Polyphenols, Older people, Aging

Citació

Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Citació

DEL BO, Cristian, MARTINI, Daniela, BERNARDI, Stefano, GIGLIOTTI, Letizia, MARINO, Mirko, GARGARI, Giorgio, MEROÑO, Tomás, HIDALGO LIBERONA, Nicole, ANDRÉS LACUEVA, Ma. cristina, KROON, Paul a., CHERUBINI, Antonio, GUGLIELMETTI, Simone, PORRINI, Marisa, RISO, Patrizia. Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects. _Antioxidants_. 2021. [consulta: 20 de gener de 2026]. ISSN: 2076-3921. [Disponible a: https://hdl.handle.net/2445/184402]

Exportar metadades

JSON - METS

Compartir registre