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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221683
Resistance to Azoles in Candida parapsilosis Isolates from Spain Is Associated with an Impairment in Filamentation and Biofilm Formation
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In recent years, there has been an increase in the incidence of fluconazole-non-susceptible (FNS) Candida parapsilosis. The reasons why these strains are able to colonize hospitals remain unknown. It is also unclear whether these strains exhibit resistance to the disinfectants used in hospitals, facilitating their spread. For these reasons, in this work, we aimed to investigate whether fluconazole resistance was associated with virulence traits and the resistance of these strains to common hospital disinfectants. The general conclusion of the study was that more than 95% of the FNS strains, regardless of the resistance mutation they carried, had filamentation problems, whereas around 75% of the susceptible strains formed pseudohyphae and were capable of filamentation. This 95% of the FNS strains did not form pseudohyphae, did not invade agar, and did not form biofilms, while the susceptible strains exhibited the opposite behaviour. Through microfluidics experiments, we observed that both the susceptible and FNS strains were capable of adhering to a plastic surface under dynamic conditions, but the FNS strains formed unstable aggregates that did not remain attached to the surface, confirming the filamentation defect of these strains. In the second part of the study, we observed that FNS strains are susceptible to clinical disinfectants, although they presented a slight resistance to some of them, such as chlorhexidine, compared to susceptible isolates. In this work, we address important aspects to understand the dissemination of FNS strains in clinical outbreaks.
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TORRES CANO, Alba, ARMENTIA, Cristina de, ROLDAN, Alejandra, LÓPEZ PERALTA, Elena, MANOSALVA, Juliana, MERINO AMADOR, Paloma, GONZÁLEZ ROMO, Fernando, PUIG ASENSIO, Mireia, ARDANUY, Carmen, MARTÍN GÓMEZ, María teresa, ROMERO HERRERO, Daniel, PÉREZ AYALA, Ana, LÓPEZ LOMBA, Marta, DURAN VALLE, María teresa, SÁNCHEZ ROMERO, Isabel, MUÑOZ ALGARRA, María, ROIZ MESONES, María pía, LARA PLAZA, Isabel, RUIZ PÉREZ DE PIPAÓN, Maite, MEGÍAS LOBÓN, Gregoria, MANTECÓN VALLEJO, María ángeles, ALCÁZAR FUOLI, Laura, MEGÍAS, Diego, ZARAGOZA, Oscar. Resistance to Azoles in Candida parapsilosis Isolates from Spain Is Associated with an Impairment in Filamentation and Biofilm Formation. _Journal of Fungi_. 2025. Vol. 11, núm. 4. [consulta: 21 de gener de 2026]. ISSN: 2309-608X. [Disponible a: https://hdl.handle.net/2445/221683]