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2021-09-30

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cc-by (c) Ortiz-Prado, Esteban et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184771

Stroke related mortality at different altitudes: A 17-year nationwide population-based analysis from Ecuador

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Recurs relacionat

https://doi.org/10.3389/fphys.2021.733928

Resum

Worldwide, more than 5.7% of the population reside above 1,500m of elevation. It has been hypothesized that acute short-term hypoxia exposure could increase the risk of developing a stroke. Studies assessing the effect of altitude on stroke have provided conflicting results, some analyses suggest that long-term chronic exposure could be associated with reduced mortality and lower stroke incidence rates. An ecological analysis of all stroke hospital admissions, mortality rates and disability-adjusted life years in Ecuador was performed from 2001-2017. The cases and population at risk were categorized in low (<1,500m), moderate (1,500m -2,500m), high (2,500m -3,500m) and very high altitude (3,500-5,500m) according to the place of residence. The derived crude and direct standardized age-sex adjusted mortality and hospital admission rates were calculated. A total of 38,201 deaths and 75,893 stroke-related hospital admissions were reported. High altitude populations (HAP) had lower stroke mortality in men (OR: 0.91 [0.88 - 0.95]) and women (OR: 0.83 [0.79 - 0.86]). In addition, HAP had a significant lower risk of getting admitted to the hospital when compared with the low altitude group in men (OR: 0.55 [CI95% 0.54 - 0.56]) and women (OR: 0.65 [CI95% [0.64 - 0.66]). This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has a stronger effect between 2,000m to 3,500 m.

Matèries

Mortalitat, Angiogènesi, Influència de l'altitud, Equador

Matèries (anglès)

Mortality, Neovascularization, Influence of altitude, Ecuador

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Citació

ORTIZ-PRADO, Esteban, ESPINOSA, Patricio s., BORRERO, Alfredo, CORDOVEZ, Simone pierina, VÁSCONEZ GONZÁLEZ, Jorge eduardo, BARRETO-GRIMALES, Alejandra, CORAL-ALMEIDA, Marco, HENRÍQUEZ-TRUJILLO, Aquiles r., SIMBAÑA-RIVERA, Katherine, GOMEZ-BARRENO, Lenin, VISCOR CARRASCO, Ginés, RODERICK, Paul. Stroke related mortality at different altitudes: A 17-year nationwide population-based analysis from Ecuador. _Frontiers in Physiology_. 2021. Vol. 12, núm. e733928, pàgs. 1-14. [consulta: 25 de febrer de 2026]. ISSN: 1664-042X. [Disponible a: https://hdl.handle.net/2445/184771]

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