Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/228778
Adhesion G protein-coupled receptors
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and to establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly evident. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in the field and provides a comprehensive assessment of the current understanding of aGPCR biology here. This includes a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches and model systems for their investigation, as well as emerging approaches for their therapeutic targeting
Subject (English)
Citation
Collections
Citation
LANGENHAN, Tobias, et al. Adhesion G protein-coupled receptors. Pharmacological Reviews. 2026. Vol. 78, num. 3, pags. 100116. ISSN 0031-6997. [consulted: 7 of June of 2026]. Available at: https://hdl.handle.net/2445/228778