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2017-09-01

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cc by (c) Hofmann et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/115969

The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea

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http://dx.doi.org/10.7554/eLife.23708

Resum

The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT02143934.

Matèries

Malària, Papua Nova Guinea, Plasmodium vivax

Matèries (anglès)

Malaria, Papua New Guinea, Plasmodium vivax

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Articles publicats en revistes (ISGlobal)

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HOFMANN, Natalie e., KARL, Stephan, WAMPFLER, Rahel, KINIBORO, Benson, TELIKI, Albina, IGA, Jonah, WALTMANN, Andreea, BETUELA, Inoni, FELGER, Ingrid, ROBINSON, Leanne j., MUELLER, Ivo. The complex relationship of exposure to new Plasmodium
                infections and incidence of clinical malaria in Papua New Guinea. _ELife_. 2017. Vol. 6, pàgs. e23708. [consulta: 23 de gener de 2026]. ISSN: 2050-084X. [Disponible a: https://hdl.handle.net/2445/115969]

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