Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

hofmann2017_2680.pdf (2.24 MB)

Document type

Article

Version

Published version

Publication date

2017-09-01

Publication license

cc by (c) Hofmann et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/115969

The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.7554/eLife.23708

Abstract

The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT02143934.

Subject

Malària, Papua Nova Guinea, Plasmodium vivax

Subject (English)

Malaria, Papua New Guinea, Plasmodium vivax

Citation

Collections

Articles publicats en revistes (ISGlobal)

Citation

HOFMANN, Natalie E., et al. The complex relationship of exposure to new Plasmodium
                infections and incidence of clinical malaria in Papua New Guinea. ELife. 2017. Vol. 6, pags. e23708. ISSN 2050-084X. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/115969

Export metadata

JSON - METS

Share record