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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230747
Theory of Multiscale Epithelial Mechanics under Stretch: From Active Gels to Vertex Models
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Epithelial monolayers perform a variety of mechanical functions, which include maintaining a cohesive barrier
or developing three-dimensional (3D) shapes, while undergoing stretches over a wide range of magnitudes and
loading rates. To perform these functions, they rely on a hierarchical organization, which spans molecules,
cytoskeletal networks, adhesion complexes, and junctional networks up to the tissue scale. While the molecular
understanding and ability to manipulate cytoskeletal components within cells is rapidly increasing, how these
components integrate to control tissue mechanics is far less understood, partly due to the disconnect between
theoretical models of subcellular dynamics and those at a tissue scale. To fill this gap, here we propose a
formalism bridging active-gel models of the actomyosin cortex and 3D vertex-like models at a tissue scale. We
focus on relatively short timescales or jammed tissues, such that tissue deformation is controlled by cellular deformations
rather than by topological transitions of the junctional network. We show that this unified framework
recapitulates a number of seemingly disconnected epithelial time-dependent phenomenologies, including stress
relaxation following stretch-unstretch maneuvers, active flattening after buckling, or nonreciprocal and nonaffine
pulsatile contractions. We further analyze tissue dynamics probed by a novel experimental setup operating in
a pressure-controlled ensemble. Overall, the proposed framework systematically connects subcellular cortical
dynamics and tissue mechanics and ties a variety of epithelial phenomenologies to a common subcellular origin.
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OUZERI, Adam, et al. Theory of Multiscale Epithelial Mechanics under Stretch: From Active Gels to Vertex Models. Prx Life (Online). 2026. Vol. 4, num. 2, pags. 023022. ISSN 2835-8279. [consulted: 10 of October of 2026]. Available at: https://hdl.handle.net/2445/230747