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2019

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176414

Brain Volumetric Correlates of Right Unilateral Versus Bitemporal Electroconvulsive Therapy for Treatment-Resistant Depression.

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https://doi.org/10.1176/appi.neuropsych.18080177

Resum

Objective: The selection of a bitemporal (BT) or right unilateral (RUL) electrode placement affects the efficacy and side effects of ECT. Previous studies have not entirely described the neurobiological underpinnings of such differential effects. Recent neuroimaging research on gray matter volumes is contributing to our understanding of the mechanism of action of ECT and could clarify the differential mechanisms of BT and RUL ECT. Methods: To assess the whole-brain gray matter volumetric changes observed after treating patients with treatment-resistant depression with BT or RUL ECT, the authors used MRI to assess 24 study subjects with treatment-resistant depression (bifrontotemporal ECT, N=12; RUL ECT, N=12) at two time points (before the first ECT session and after ECT completion). Results: Study subjects receiving BT ECT showed gray matter volume increases in the bilateral limbic system, but subjects treated with RUL ECT showed gray matter volume increases limited to the right hemisphere. The authors observed significant differences between the two groups in midtemporal and subcortical limbic structures in the left hemisphere. Conclusions: These findings highlight that ECT-induced gray matter volume increases may be specifically observed in the stimulated hemispheres. The authors suggest that electrode placement may relevantly contribute to the development of personalized ECT protocols.

Matèries

Depressió psíquica, Cervell, Diagnòstic per la imatge, Electroteràpia

Matèries (anglès)

Mental depression, Brain, Diagnostic imaging, Electrotherapeutics

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

CANO CATALÀ, Marta, LEE, Erik, CARDONER, N. (narcís), MARTÍNEZ ZALACAÍN, Ignacio, PUJOL, Jesús, MAKRIS, Nikos, HENRY, Michael, VIA VIRGILI, Esther, HERNÁNDEZ RIBAS, Rosa, CONTRERAS RODRÍGUEZ, Oren, MENCHÓN MAGRIÑÁ, José manuel, URRETAVIZCAYA SARACHAGA, Mikel, SORIANO MAS, Carles, CAMPRODON, Joan a.. Brain Volumetric Correlates of Right Unilateral Versus Bitemporal Electroconvulsive Therapy for Treatment-Resistant Depression.. _Journal of Neuropsychiatry and Clinical Neurosciences_. 2019. Vol. 31, núm. 2, pàgs. 152-158. [consulta: 20 de gener de 2026]. ISSN: 0895-0172. [Disponible a: https://hdl.handle.net/2445/176414]

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