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2013-04-24

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/130725

A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma

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https://doi.org/10.1002/ana.23917

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Among 249 patients with teratoma‐associated encephalitis, 211 had N‐methyl‐D‐aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody‐positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody‐negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range = 12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome.

Matèries

Teratoma, Encefalitis, Tumors cerebrals

Matèries (anglès)

Teratoma, Encephalitis, Brain tumors

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Articles publicats en revistes (Medicina)

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ARMANGUÉ, Thaís, et al. A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma. Annals of Neurology. 2013. Vol. 75, num. 3, pags. 435-441. ISSN 0364-5134. [consulted: 24 of May of 2026]. Available at: https://hdl.handle.net/2445/130725

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