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Article

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Published version

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2000-07-07

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/54944

Evidence of an efflux pump in Serratia marcescens

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http://dx.doi.org/10.1089/107662900419410

Abstract

Spontaneous mutants resistant to fluoroquinolones were obtained by exposing Serratia marcescens NIMA (wild-type strain) to increasing concentrations of ciprofloxacin both in liquid and on solid media. Frequencies of mutation ranged from 10-7 to 10-9. Active expulsion of antibiotic was explored as a possible mechanism of resistance in mutants as well as changes in topoisomerase target genes. The role of extrusion mechanisms in determining the emergence of multidrug-resistant bacteria was also examined. Mutants resistant to high concentrations of fluoroquinolones had a single mutation in their gyrA QRDR sequences, whereas the moderate resistance in the rest of mutants was due to extrusion of the drug

Subject

Resistència als medicaments, Antibiòtics, Serratia marcescens, Medicaments antibacterians

Subject (English)

Drug resistance, Antibiotics, Serratia marcescens

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Citation

BERLANGA HERRANZ, Mercedes, et al. Evidence of an efflux pump in Serratia marcescens. Microbial Drug Resistance. 2000. Vol. 6, num. 2, pags. 111-117. ISSN 1076-6294. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/54944

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