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Evidence of an efflux pump in Serratia marcescens
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Spontaneous mutants resistant to fluoroquinolones were obtained by exposing Serratia marcescens NIMA (wild-type strain) to increasing concentrations of ciprofloxacin both in liquid and on solid media. Frequencies of mutation ranged from 10-7 to 10-9. Active expulsion of antibiotic was explored as a possible mechanism of resistance in mutants as well as changes in topoisomerase target genes. The role of extrusion mechanisms in determining the emergence of multidrug-resistant bacteria was also examined. Mutants resistant to high concentrations of fluoroquinolones had a single mutation in their gyrA QRDR sequences, whereas the moderate resistance in the rest of mutants was due to extrusion of the drug
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BERLANGA HERRANZ, Mercedes, et al. Evidence of an efflux pump in Serratia marcescens. Microbial Drug Resistance. 2000. Vol. 6, num. 2, pags. 111-117. ISSN 1076-6294. [consulted: 22 of May of 2026]. Available at: https://hdl.handle.net/2445/54944