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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/125021
Enantioselective preparation of delta-valerolactones using horse liver alcohol dehydrogenase
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Horse liver alcohol dehydrogenase (HLADH) has been found to be a versatile biocatalyst for the desymmetrization of prochiral 3‐arylpentane‐1,5‐diols, based on a two‐step one‐pot oxidation. This procedure has allowed the formation of valuable (S)‐lactones in good to excellent conversions and enantiomeric excess. The catalytic performance of HLADH has been studied using several cofactor regeneration systems and cosolvents, finding great improvements in terms of activity with L‐lactate dehydrogenase, while the stereoselectivity of the process was significantly improved when using tetrahydrofuran. Docking studies has revealed the pattern substitution importance in the selectivity and activity of this oxidative process
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DÍAZ-RODRÍGUEZ, Alba, et al. Enantioselective preparation of delta-valerolactones using horse liver alcohol dehydrogenase. ChemCatChem. 2013. Vol. 6, num. 4, pags. 977-980. ISSN 1867-3880. [consulted: 7 of June of 2026]. Available at: https://hdl.handle.net/2445/125021