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Article

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2019-03-26

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cc-by (c) Zhu, Yunqing, et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/216542

Metabolically Active, Fully Hydrolysable Polymersomes

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https://doi.org/https://doi.org/10.1002/anie.201814320

Abstract

The synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.

Subject

Agents tensioactius, Polièsters, Química

Subject (English)

Surface active agents, Polyesters, Chemistry

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Articles publicats en revistes (Física Aplicada)

Citation

ZHU, Yunqing, et al. Metabolically Active, Fully Hydrolysable Polymersomes. Angewandte Chemie-International Edition. 2019. Vol. 58, num. 14, pags. 4581-4586. ISSN 1433-7851. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/216542

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