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1996

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/25845

Effect of expiratory flow limitation on respiratory mechanical impedance: a model study

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Abstract

Large phasic variations of respiratory mechanical impedance (Zrs) have been observed during induced expiratory flow limitation (EFL) (M. Vassiliou, R. Peslin, C. Saunier, and C. Duvivier. Eur. Respir. J. 9: 779-786, 1996). To clarify the meaning of Zrs during EFL, we have measured from 5 to 30 Hz the input impedance (Zin) of mechanical analogues of the respiratory system, including flow-limiting elements (FLE) made of easily collapsible rubber tubing. The pressures upstream (Pus) and downstream (Pds) from the FLE were controlled and systematically varied. Maximal flow (Vmax) increased linearly with Pus, was close to the value predicted from wave-speed theory, and was obtained for Pus-Pds of 4-6 hPa. The real part of Zin started increasing abruptly with flow (V) >85%Vmax and either further increased or suddenly decreased in the vicinity of V¿max. The imaginary part of Zin decreased markedly and suddenly above 95%Vmax. Similar variations of Zin during EFL were seen with an analogue that mimicked the changes of airway transmural pressure during breathing. After pressure andV measurements upstream and downstream from the FLE were combined, the latter was analyzed in terms of a serial (Zs) and a shunt (Zp) compartment. Zs was consistent with a large resistance and inertance, and Zp with a mainly elastic element having an elastance close to that of the tube walls. We conclude that Zrs data during EFL mainly reflect the properties of the FLE.

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Respiració, Pulmó, Models biològics

Subject (English)

Respiration, Lung, Biological models

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Articles publicats en revistes (Ciències Fisiològiques)

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PESLIN, René, et al. Effect of expiratory flow limitation on respiratory mechanical impedance: a model study. Journal of Applied Physiology. 1996. Vol. 81, num. 6, pags. 2399-2406. ISSN 8750-7587. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/25845

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