RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease

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dc.contributor.authorPérez Sisqués, Leticia
dc.contributor.authorSancho Balsells, Anna
dc.contributor.authorSolana Balaguer, Júlia
dc.contributor.authorCampoy Campos, Genís
dc.contributor.authorVives Isern, Marcel
dc.contributor.authorSoler Palazón, Ferran
dc.contributor.authorAnglada Huguet, Marta
dc.contributor.authorLópez Toledano, Miguel Ángel
dc.contributor.authorMandelkow, Eva Maria
dc.contributor.authorAlberch i Vié, Jordi, 1959-
dc.contributor.authorGiralt Torroella, Albert
dc.contributor.authorMalagelada Grau, Cristina
dc.date.accessioned2024-02-16T14:21:57Z
dc.date.available2024-02-16T14:21:57Z
dc.date.issued2021-06-15
dc.date.updated2024-02-16T14:21:57Z
dc.description.abstractWe found an unanticipated recovery of several gliosis hallmarks and inflammasome key proteins upon neuronal RTP801 downregulation in the 5xFAD mice. Altogether our results suggest that RTP801 could be a potential future target for theranostic studies since it could be a biomarker of neuroinflammation and neurotoxicity severity of the disease and, at the same time, a promising therapeutic target in the treatment of AD.
dc.format.extent13 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec713034
dc.identifier.issn2041-4889
dc.identifier.pmid34131105
dc.identifier.urihttps://hdl.handle.net/2445/207668
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofCell Death and Disease, 2021, vol. 12, num.6
dc.rightscc-by (c) Pérez Sisqués, Leticia et al., 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Biomedicina)
dc.subject.classificationCervell
dc.subject.classificationMort cel·lular
dc.subject.classificationMalaltia d'Alzheimer
dc.subject.classificationMalalties cerebrals
dc.subject.classificationProteïnes
dc.subject.otherBrain
dc.subject.otherCell death
dc.subject.otherAlzheimer's disease
dc.subject.otherBrain diseases
dc.subject.otherProteins
dc.titleRTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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