Files

240384.pdf (4.88 MB)

Document type

Article

Version

Published version

Publication date

2021-06-15

Publication license

cc-by (c) Pérez Sisqués, Leticia et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/207668

RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

Abstract

We found an unanticipated recovery of several gliosis hallmarks and inflammasome key proteins upon neuronal RTP801 downregulation in the 5xFAD mice. Altogether our results suggest that RTP801 could be a potential future target for theranostic studies since it could be a biomarker of neuroinflammation and neurotoxicity severity of the disease and, at the same time, a promising therapeutic target in the treatment of AD.

Subject

Cervell, Mort cel·lular, Malaltia d'Alzheimer, Malalties cerebrals, Proteïnes

Subject (English)

Brain, Cell death, Alzheimer's disease, Brain diseases, Proteins

Citation

Collections

Articles publicats en revistes (Biomedicina)

Citation

PÉREZ SISQUÉS, Leticia, et al. RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease. Cell Death and Disease. 2021. Vol. 12, num. 6. ISSN 2041-4889. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/207668

Export metadata

JSON - METS

Share record