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Aged lipid-laden microglia display impaired_EMBO MolecularMedicine.pdf (4.34 MB)

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2023-02-08

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cc by (c) Arbaizar Rovirosa, Maria et al, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198581

Aged lipid-laden microglia display impaired responses to stroke

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Recurs relacionat

https://doi.org/10.15252/emmm.202217175

Resum

Microglial cells of the aged brain manifest signs of dysfunction that could contribute to the worse neurological outcome of stroke in the elderly. Treatment with colony-stimulating factor 1 receptor antagonists enables transient microglia depletion that is followed by microglia repopulation after treatment interruption, causing no known harm to mice. We tested whether this strategy restored microglia function and ameliorated stroke outcome in old mice. Cerebral ischemia/reperfusion induced innate immune responses in microglia highlighted by type I interferon and metabolic changes involving lipid droplet biogenesis. Old microglia accumulated lipids under steady state and displayed exacerbated innate immune responses to stroke. Microglia repopulation in old mice reduced lipid-laden microglia, and the cells exhibited reduced inflammatory responses to ischemia. Moreover, old mice with renewed microglia showed improved motor function 2 weeks after stroke. We conclude that lipid deposits in aged microglia impair the cellular responses to ischemia and worsen functional recovery in old mice.© 2022 The Authors. Published under the terms of the CC BY 4.0 license.

Matèries

Isquèmia cerebral, Micròglia

Matèries (anglès)

Cerebral ischemia, Microglia

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

ARBAIZAR ROVIROSA, Maria, et al. Aged lipid-laden microglia display impaired responses to stroke. Embo Molecular Medicine. 2023. Vol. 15, num. 2. ISSN 1757-4684. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/198581

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