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1-s2.0-S0376871623000601-main.pdf (638.08 KB)

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2023-04-01

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cc by-nc-nd (c) Hernández Rubio, Anna et al, 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198665

Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

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https://doi.org/10.1016/j.drugalcdep.2023.109822

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Introduction: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.Patients and Methods: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.Results: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimen-tation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 >= 3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.Conclusions: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.

Matèries

Alcoholisme, Dèficit de magnesi

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Alcoholism, Magnesium deficiency diseases

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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HERNÁNDEZ RUBIO, Anna, SANVISENS, Arantza, BARBIER TORRES, Lucía, BLANES, Rafael, MIQUEL DE MONTAGUT, Laia, TORRENS, Marta, RUBIO, Gabriel, BOLAO, Ferran, ZULUAGA, Paola, FUSTER, Daniel, RODRÍGUEZ DE FONSECA, Fernando, FARRÉ ALBALADEJO, Magí, MUGA, Robert, CohRTA Study, PAPASSEIT, Esther, PÉREZ MAÑÁ, Clara, POYATOS, Lourdes, GARCÍA MARCHENA, Nuria, ABELLÍ, Enric, SHORT, Antoni, MORANTA, Catalina, SION, Ana, ORTEGA, Lluisa, BRUGUERA SOLER, Pol, CABALLERIA, Elsa, MESSEGUER, Ana, FONSECA, Francina, MESTRE PINTO, Juan ignacio, ALÍAS, María, DINAMARCA, Fernando, PAVÓN MORÓN, Francisco javier, ARAOS, Pedro, FLORES LÓPEZ, María, SERRANO, Antonia, MARCOS, Miguel, MARTÍN GONZÁLEZ, M. candelaria, PÉREZ HERNÁNDEZ, Onán, MANZANARES, Jorge, ILLESCAS, Lucía. Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder. _Drug and Alcohol Dependence_. 2023. Vol. 245. [consulta: 8 de abril de 2026]. ISSN: 1879-0046. [Disponible a: https://hdl.handle.net/2445/198665]

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